Office of
Research

College of Human Medicine




Office of
Research

Total Value Name of Award / Description of Study Project Start Project End Awarded by Principal Investigator Unit
$1,500,000 State Opioid Response Grant providing technical assistance for physicians going through the practice pathway to become board certified in Addiction Medicine. 12/01/18 11/01/21 State of Michigan Cara Poland, MD, MEd, FACP, DFASAM Kelly Strutz, PhD, MPH Obstetrics, Gynecology and Reproductive Biology
$90,340 Dissecting the Transcriptional Network Governing Differentiation of Periderm 9/21/2018 9/20/2019 National Institute of Health Brian Schutte, PhD, Associate Professor Pediatrics and Human Development
Total Value Name of Award / Description of Study Project Start Project End Awarded by Principal Investigator Unit
$1,609,214 Modulation of the Receptive Endometrium and Decidualization by Notch 9/12/16 5/31/21 NIH - NICHHD Asgi Fazleabas, PhD, Professor and Associate Chair of Research, Co-Director of the Reproductive and Developmental Science Program OB/GYN & Reproductive Biology
$1,607,347 Risk Factors for Early Pregnancy Loss 4/10/16 3/31/21 NIH - NICHHD Jae Wook Jeong, PhD OB/GYN & Reproductive Biology
$698,251 Family Smoking Cessation in Romania Using Pregnancy as a Window of Opportunity 12/1/14 11/30/19 NIH - Department of Health and Human Services Cristian Meghea, PhD OB/GYN & Reproductive Biology
$761,383 The Role of PPAR in Human Placental Development and Preeclampsia 4/1/18 3/31/20 NIH - Department of Health and Human Services Sascha Drewlo, PhD OB/GYN & Reproductive Biology
$546,755 Marriott Fund for Clinical Innovation in Endometriosis 8/16/16 12/31/20 J. Willard and Alice S. Marriott Foundation Stacey Missmer, ScD OB/GYN & Reproductive Biology
$1,717,799 Role of microRNA in the Pathophysiology of Endometriosis 4/1/16 1/31/21 NIH - NICHHD Asgi Fazleabas, PhD, Professor and Associate Chair of Research, Co-Director of the Reproductive and Developmental Science Program OB/GYN & Reproductive Biology
$38,676 Identifying Neuroinflammation in Glioblastoma 6/27/18 12/31/19 Spectrum Health System Jeffrey MacKeigan, PhD OB/GYN & Reproductive Biology
$235,337 Integrative Analysis of Genomic, Epigenomic and Phenotypic Data for DiseaseStratification of Endometriosis 9/26/16 4/30/21 University of California San Francisco Stacey Missmer, ScD OB/GYN & Reproductive Biology
$220,988 Subfertility and Assisted Conception Study of Parent and Child Health Outcomes 6/23/16 3/31/21 NIH Stacey Missmer, ScD OB/GYN & Reproductive Biology
$1,567,790 Michigan CARES (Collaborative Addiction Resources and Education System) 12/1/18 9/30/20 Michigan Dept of Health and Human Services Kelly Strutz, PhD OB/GYN & Reproductive Biology
$202,765 Strong Beginnings (Healthy Start Initiative – Eliminating Racial/Ethnic Disparities) 11/1/14 3/31/19 Spectrum Health System Kelly Strutz, PhD
LeeAnne Roman, PhD
OB/GYN & Reproductive Biology
Total ValueName of Award / Description of StudyProject StartProject EndAwarded byPrincipal InvestigatorUnit
$3,868,014 What is Endometriosis? Deep Phenotyping to Advance Diagnosis and Treatment The goal of the study is to identify unique classifications of endometriosis patients that inform non-invasive diagnostics, response to current treatments, and novel treatment pathways - stratifying discoveries by participant symptom presentation, and for the cases, by surgical and imaging visualized disease characteristics to capture the full heterogeneity of endometriosis. 9/1/2018 8/31/2023 NIH Stacey Missmer, ScD Professor Department of Obstetrics, Gynecology and Reproductive Biology
$2,960,000 Geroscience approaches to mitigate tauopathy in aged mouse brain/ This project will determine whether controlling the rate of biological aging using calorie restriction, rapamycin therapy and therapies to deplete senescent cells will ameliorate Alzheimer-like pathology in a mouse model. 9/30/2018 5/31/20232 NIH/ National Institute on Aging Marcia N. Gordon, Ph.D., Professor; Co-Investigators: Scott E. Counts, Ph.D., Associate Professor and David G. Morgan, Ph.D., Professor Translational Science and Molecular Medicine
$2,786,857 Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for PD. 9/30/2018 6/30/2023 NIH/NINDS Kathy Steece-Collier, Ph.D, Professor; Co-PI: Fredric P. Manfredsson, Ph.D., Assistant Professor; Col: Timothy J. Collier, Ph.D., Professor Translational Science and Molecular Medicine
$1,414,478 Is the Treatment Perceived to be Worse than the Disease?: Ethical Concerns and Attitudes towards Psychiatric Electroceutical Interventions 9/01/2018 8/01/2022 National Institutes of Health BRAIN Initiative Laura Y. Cabrera, PhD; Assistant Professor, Center for Ethics and Humanities in the Life Sciences, and Department of Translational Science and Molecular Medicine, College of Human Medicine. Center for Ethics and Humanities for Life Sciences
$632,262 Preventing Alzheimer's Disease with Cognitive Training (the PACT Trial) 9/30/2018 8/31/2019 NIH/NIA David G. Morgan, Ph.D., Professor Translational Science and Molecular Medicine
$349,547 New Supplement R01 for "Gut-Brain Axis in Alzheimer’s Disease" 2/01/2019 1/31/2020 NIH Fredric P. Manfredsson, Ph.D., Assistant Professor Translational Science and Molecular Medicine
$72,654 BDefining Mechanistic Targets and Circulating Biomarkers to Therapeutic Response and Resistance to Clinical ATR and Chk1 Inhibitors in High-Grade Ovarian Cancer 7/15/2018 7/14/2020 Henry Jackson Foundation John Risinger, PhD Professor Department of Obstetrics, Gynecology and Reproductive Biology
$61,678 Virally Induced Metabolomic Dysregulation Associated with Viral Bronchiolitis Infections in Pediatric Patients: Working Towards a Precision Medicine Approach 10/5/2018 12/31/2018 Spectrum Health System Andre Bachmann, PhD, Professor Sophia Lunt, PhD, Assistant Professor Pediatrics and Human Development
$4,000 Biomarin Study 270-902 4/30/2018 4/30/2021 BioMarin Pharmaceutical Inc Roshni Kulkarni, MD, Professor Pediatrics and Human Development
Total ValueName of Award / Description of StudyProject StartProject EndAwarded byPrincipal InvestigatorUnit
$1,521,143 DNA Structure Directed AID Deamination During Immunoglobulin Isotype Switching 7/24/18 6/30/22 NIH Kefei Yu, PhD
Associate Professor
Microbiology and Molecular Genetics
$461,318 Novel ODC Inhibitor Phaseolotoxin n Neuroblastoma 8/21/18 7/31/20 National Cancer Institute Andre Bachmann, PhD, Professor, Associate Chair for Research, David Monsma, Industrial Hygienist, Thomas Dexheimer, PhD, Manager of Assay Development and Drug Repurposing, Edmund Ellsworth, PhD, Professor Pediatrics and Human Development
$451,111 Targeting Glucose Metabolism for the Treatment of Hepatocellular Carcinoma 4/1/18 7/31/19 NIH Bin Chen, PhD, Assistant Professor Pediatrics and Human Development
$426,250 Mechanistic understanding of HIV-1 broad neutralizing antibody evolution 2/7/18 1/31/20 NIH Kefei Yu, PhD
Associate Professor
Microbiology and Molecular Genetics
$420,546 A novel mouse model to study DNA ligase 3 function in vivo 5/21/18 4/30/20 NIH Kefei Yu, PhD
Associate Professor
Microbiology and Molecular Genetics
$98,050 Improving Pharmacokinetics and Efficacy of DFMO in Neuroblastoma 7/1/18 6/30/19 St. Baldrick's Foundation Andre' Bachmann, PhD, Professor, Associate Chair for Research Pediatrics and Human Development
$85,000 URMC-099 in in vivo AAV-hSYN and in vitro Dopaminergic Neuron Models 9/1/18 12/31/19 Michael J. Fox Foundation Fredric P. Manfredsson, Ph.D., Assistant Professor Translational Science and Molecular Medicine
$7,531 Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Prophylaxis and Treatment of Bleeds in Previously N8-GP Treated Patients with Severe Haemophilia 4/1/18 3/31/21 Novo Nordisk Roshi Kulkarni, MD, Professor
Ajovi Scott-Emuakpor, MD, Professor
Jatin Rana, MD, Assistant Professor
Renuka Gera, MD, Professor, Assistant Dean
Aghiad Chamdin, MD, Assistant Professor
Pediatrics and Human Development
$3,500 A Global Epidemiologic Study to Determine the Prevalence of Neutralizing Antibodies and Related Adaptive Immune Responses to Adeno-Associated Virus (AAV) in Adults with Hemophilia 1/26/18 12/31/22 Baxalta US Inc Roshni Kulkarni, MD, Professor
Ajovi Scott-Emuakpor, MD, Professor
Jatin Rana, MD, Assistant Professor
Renuka Gera, MD, Professor, Assistant Dean
Aghiad Chamdin, MD, Assistant Professor
Pediatrics and Human Development
$5,765 Evaluation of Safety  Following Immune Tolerance Induction Treatment with Turoctocog Alfa in Patients with Hemophilia A Following Inhibitor Development in NN7170-4213 Trial 12/14/17 11/30/21 Novo Nordisk Roshni Kulkarni, MD, Professor Pediatrics and Human Development
$208,333 Evaluation of Silicosis, Asthma and COPD among Sand and Gravel and Stone Surface Miners”

Injury and Disease Exposure and Risk Factors - Examination of the Relationships between Mine Environment Exposures and the Development or Exacerbation of Asthma and COPD
1-Jul-18 31-Dec-19 Alpha Foundation Kenneth Rosenman
Professor of Medicine
Chief, Division of Occupational and Environmental Medicine
MSU Distinguished Professor Award (2010)
Medicine
$135,076 Environmental Microbial and Mammalian Biomolecular Responses to AhR Ligands - Administrative Supplement 7/13/18 3/31/19 NIEHS/NIH Brad Upham, PhD, Associate Professor Pediatrics and Human Development
$296,137 New Survival Analysis Methods for Longitudinal Studies of Childhood Dental Caries 7/1/18 6/30/20 NIH Chenxi Li, PhD, Assistant Professor Epidemiology and Biostatistics
$1,325,365 Methods and Software for High-dimensional Risk Prediction Research 7/1/18 5/31/22 NIH/Library of Medicine Qing Lu, PhD, Associate Professor Epidemiology and Biostatistics
$151,399 Impact Award - Prodromal Symptoms in the Sister Study 6/1/18 5/31/19 Parkinson's Disease Fd. Honglei Chen, MD, PhD, Professor Epidemiology and Biostatistics
$500,000 Food as Medicine for Older Adults with Chronic Health Conditions 7/1/18 6/30/20 MI Health Endowment Fund Jean Kerver, PhD, MSc, RD, Assistant Professor Epidemiology and Biostatistics
$3,000 Norman Kagan Endowed Scholarship in Graduate and Professional Studies, project title: Building Skills for End-of-Life Discussions in the Intensive Care Environment. bioethics.msu.edu/homepage/research 1-Jul-18 30-Apr-19 MSU Devan Stahl, PhD, Assistant Professor, Center for Ethics and Humanities in the Life Sciences and Department of Pediatrics and Human Development. Center for Ethics and Humanities in the Life Sciences
Total ValueName of Award / Description of StudyProject StartProject EndAwarded byPrincipal InvestigatorUnit
$300,000 Genetic Link Between Aging and Parkinson’s Disease 2018 2021 Gibby & Friends vs Parky Timothy J. Collier, Ph.D., Professor Translational Science and Molecular Science
$296,137 New Survival Analysis Methods for Longitudinal Studies of Childhood Dental Caries 07/01/2018 06/30/2020 NIH, RO3 Chenxi Li, PhD, Assistant Professor Epidemiology and Biostatistics
$300,000 BDNF Precision medicine for Parkinson’s disease 2018 2021 Gibby & Friends vs Parky Caryl E. Sortwell, Ph.D. Professor and Associate Translational Science and Molecular Science
$200,000 LRRK2 and Tau in Parkinson’s Disease 2018 2020 Gibby & Friends vs Parky Nicholas M. Kanaan, Ph.D., Associate Professor Translational Science and Molecular Science
$20,000 2018 Pearl J. Aldrich Award 07/01/2018 06/30/2019 Pearl J. Aldrich Endowment Caryl E. Sortwell, Ph.D. Professor and Associate Translational Science and Molecular Science
Total ValueName of Award / Description of StudyProject StartProject EndAwarded byPIUnit
$15,000 The Role of Priostin in Uterine Fibroid Pathogenesis 07/01/2018 06/30/2019 Society for Reproductive Investigation Amanda Patterson, PhD OB/GYN & Reproductive Biology
$31,375 Rho Kinase Inhibition via Brain-Penetrant Kadmon Compound for Neuroprotection in Parkinson's Disease 02/01/2018 01/31/2019 Michael J Fox Foundation Jeffrey MacKeigan, PhD OB/GYN & Reproductive Biology and
Translational Science and Molecular Medicine
$1,540,162 Implementing to sustain: Determining the minimum necessary intervention to maintain a postpartum depression prevention program (ROSE) in clinics providing prenatal services to low-income women 01/01/2018 12/31/2022 National Institute of Mental Health Jennifer Johnson, PhD Division of Public Health
$50,000 Mitochondrial disfunction in ARID1A mutant ovarian clear cell cancer. 07/01/2018 06/30/2019 MI Ovarian Cancer Alliance John Risinger, PhD OB/GYN & Reproductive Biology
$50,000 Study of the Molecular Mechanisms Involved in High Grade Serous Progression from Metaplasia 06/01/2018 05/31/2019 MI Ovarian Cancer Alliance Jose Teixeira, PhD OB/GYN & Reproductive Biology
$25,000 RAIND Seed Grant 07/01/2018 12/31/2019 MSU Karen Racicot, PhD OB/GYN & Reproductive Biology
$163,500 Defining the role of endometrium in endometriosis-associated ovarian cancer 01/01/2018 12/31/2020 American Cancer Society Michael Wilson, PhD OB/GYN & Reproductive Biology
$15,000 Therapeutic Targeting of Endometriotic Lesions by NOTCH Inhibition 07/01/2018 06/30/2019 Society for Reproductive Investigation Niraj Joshi, PhD OB/GYN & Reproductive Biology
$2,956,535 Women's Outcomes Research and Knowledge (WORK) 04/01/2018 03/31/2021 AbbVie Stacey Missmer, ScD OB/GYN & Reproductive Biology
$31,000 Translational Research in Pelvic Pain (TRiPP) 01/01/2018 03/31/2021 Oxford University Stacey Missmer, ScD OB/GYN & Reproductive Biology
Total ValueName of Award / Description of StudyProject StartProject EndAwarded byPrincipal InvestigatorUnit
$168,290 Rho Kinase Inhabitation via Brain-Penetrant Kadmon Compound for Neuroprotection in Parkinson’s Disease 04/13/2018 04/13/2019 The Michael J. Fox Foundation Caryl E. Sortwell, Ph.D. Professor and Associate Chair and Jeff MacKeigan, Ph.D., Professor Translational Science & Molecular Medicine and Obstetrics Gynecology & Reproductive Biology
$100,000 Modulation of Alpha-synuclein Expression via Beta 2-Adrenoreceptor Agonist Clenbuterol in the Preformed Fibril Synucleinopathy Model 06/01/2018 06/01/2019 The Michael J. Fox Foundation PI - Joseph R. Patterson, Ph.D., Postdoctoral Fellow Co-PI - Caryl E. Sortwell, Ph.D., Professor and Associate Chair Translational Science and Molecular Science
$309,094 Parkinson's Research Program Early Investigator Research Award for "Harnessing Neuropasticity Genes to Combat Synucleinopathy-Mediated Axonopathy" TBA TBA Parkinson's Research Program Joseph Patterson, Ph.D., Postdoctoral Fellow Translational Science and Molecular Science
$250,000 Evaluation of Silicosis, Asthma and COPD among Sand and Gravel and Stone Surface Miners. TBA TBA Alpha Foundation for the Improvement of Mine Safety and Health, Inc. Kenneth Rosenman, M.D. Division of Occupational & Environmental Medicine
$75,000 Worksite Intervention to Mitigate Child Take-Home Lead Exposure This 1-year proposal will implement a program of take-home lead exposure. TBA TBA Michigan Department of Health and Human Services PI: Kenneth Rosenman, M.D. Professor of Medicine Chief, Division of Occupational and Environmental Medicine Co-PI: Anthony Oliveri, PhD, MPH Assistant Professor Division of Occupational & Environmental Medicine Division of Occupational & Environmental Medicine